Nonsteroidal anti-inflammatory drugs (NSAIDs) that help control the pain and inflammation in individuals with osteoarthritis (OA), may lead to cardiovascular side effects, reveals a new study.
The study was published in the journal Arthritis & Rheumatology.
The study matched 7,743 OA patients with 23,229 non-OA controls. The risk of developing cardiovascular disease among people with OA was found to be 23% higher compared with people without OA.
Among secondary outcomes assessed in the study, the risk of congestive heart failure was 42% higher among people with OA compared with people without OA, followed by a 17% greater risk of ischaemic heart disease and a 14% greater risk of stroke.
Researchers found that approximately 41% of the increased risk of cardiovascular disease among people with OA was mediated through their NSAID use.
“Our results indicate that osteoarthritis is an independent risk factor for cardiovascular disease and suggest a substantial proportion of the increased risk is due to the use of NSAIDs,” said Aslam Anis, senior author of the study.
“This is highly relevant because NSAIDs are some of the most commonly used drugs to manage pain in patients with osteoarthritis. It’s important for people with OA to talk to their care providers and discuss the risks and benefits of NSAIDs,” he said.