Fujifilm launches Apollo X mammalian expression systemMarch 5, 2019
Fujifilm Diosynth Biotechnologies has introduced Apollo mammalian expression system, Apollo X.
The Apollo X advanced mammalian expression system is capable of delivering titres in excess of 10 g/L.
CHO-DG44-derived host cell line selected through a directed evolution approach to control and manage cellular heterogeneity, is
one of the key components of the system. The selected cell line has been fully sequenced and analysed, a novel expression vector with a proprietary leader sequence developed for efficient secretion and high productivities without the need for amplification.
Its cell culture medium is specifically screened for achieving high titres by monitoring initial cell growth, controlling peak
cell density and maintaining high cell viability, streamlined units of operations for efficient process implementation.
Apollo X cell line development timelines have been reduced by 30%, from gene to clonal cell line compared to the original Apollo expression system.