Nanotech-2018 showcases exciting world of nanomedicineFebruary 4, 2019
Nanotechnology offers exciting possibilities in medicine and medical applications for the near future. While some of the unique applications using these possibilities are still in the conceptual stage, many are already in trials or being applied in treatment and disease management. These promising technologies, involving applications of nanoparticles or nano-robots to make repairs at the cellular level, are predicted to revolutionize the way the medical world detects and treats diseases.
Nanotech-2018, the one-day annual nanotechnology seminar, was jointly organised by Center for Nanoscience and Technology, Anna University, Chennai with Slovak Academy of Sciences, Slovakia, and MagGenome Technologies Pvt. Ltd on 7 December in Chennai. It showcased some of these techniques, which were only imagined a few years ago, as they are making their way into the market.
Explaining the novel concept of developing iron oxide nanoparticles as solid support for affinity and hydrophobic ligands, Dr Tessy Iype, scientist at MagGenome Technologies, said that a novel method of immobilizing affinity ligands developed by MagGenome will potentially open up a whole new avenue for purification of proteins, especially monoclonal antibodies using a magnetic system.
“This will provide researchers a quick and cost-effective method in reagent or therapeutic antibody purification, compared to the existing column-based technology. Our long-term goal is to provide a unique and robust automated magnetic system for effective purification of therapeutic antibodies,” she added.
While many Indian scientists from promising research start-ups and scientific organisations have already displayed significant breakthroughs in this field, there are promising large-scale projects also underway in the world.
A recent study performed by Institute of Experimental Physics, Slovak Academy of Sciences showed its high-potential use of magneto ferritin in various biomedical applications, including targeted transport, MRI and nanocatalytic chemistry.
Ferritin, which is a naturally occurring iron-storage protein, is essential for iron homeostasis and is involved in a wide range of physiologic and pathologic processes in our body. The magnetic properties of ferritin nanoparticles play an important role in nanoengineering and biomedical applications. Magnetoferritin biomacromolecule consist of an apoferritin shell that surrounds an inorganic core of magnetic iron oxides, varying in the size according to the amount of iron ions.
“We have proved that magnetoferritin plays a significant biomedical role with its potential anti-amyloid activity and it helps in the diagnosis of neurodegenerative diseases using magneto-optical method. Magnetoferritin and reconstructed ferritin is also able to destruct lysozyme amyloid fibrils, helping reverse the process of aggregation. H2O2 accumulation causes oxidative stress, leading to physiological conditions of cardiovascular, cancer, neurodegenerative diseases. The peroxidase-like activity of magnetoferritin can provide a model system of pathological ferritin effect on H2O2 in vitro,” said Dr Peter Kopcansky, Director, Institute of Experimental Science at Slovak Academy of Science, in his keynote address.
According to Milan Timko, head, Department of Magnetism at the Institute of Experimental Physics, Slovak Academy of Sciences, another promising study has revealed the possibility of a new innovative thermal-method coupling magnetic and ultrasonic hyperthermia as a promising heat therapy for cancer treatment.
Hyperthermia is a biomedical application of magnetic nanoparticles. Mechanical oscillation of magnetic nanoparticles using ultrasonic waves can be converted into thermal energy which increasing temperature in the treatment of tumour affected zone.
“In Vivo Testing of Magnetic Hyperthermia showed remarkable regression of tumours with magnetic hyperthermia in mice models in previous studies. This study focussed on the effect of simultaneous interaction of ultrasounds and alternate current (AC) magnetic field with magnetic nanoparticles (MNPs) with a rise in temperature in agar phantoms doped with MNP,” Dr Timko said.
Using magnetic nanoparticles as a tool for extracting DNA, total protein and bioanalytical extraction of drugs was another path-breaking technology that was discussed at the Seminar. This research proposed by MagGenome Technologies offers an alternate method for bioanalytical extraction of drugs from human plasma samples using bare magnetic nanoparticles.
“The seminar mainly focused on biological applications of various types of nanoparticles and the major emphasis was given to the development of novel technologies which are technically superior and commercially viable,” said Dr C N Ramchand, chief executive officer, MagGenome Technologies, and convenor of Nanotech-2018.
The other key speakers at the Seminar included Dr Sailaja Elchuri of Sankara Nethralaya, Dr Narayana Kalkura of Anna University, Dr Anima Nanda of Satyabhama University, Dr P Balakrishna Murthy of Hiroshima University, Dr Aniruddha Bhati of MagGenome Technologies and Dr C. Gopalakrishnan of SRM University.