Early appendix removal may delay Parkinson’sJanuary 14, 2019
Killinger et al reported that the removal of the appendix at an early age may delay or reduce the occurrence risk of Parkinson’s disease (PD) in those individuals. The scientists observed a remarkably abundant presence of a misfolded protein α-synuclein in the appendix of both normal individuals and PD patients which was analogous to that found in post-mortem brain tissues of patients with PD. The study included two large-scale epidemiological datasets which involved more than 1.6 million individuals and over 91 million person-years which revealed that the removal of appendix decades before PD onset was associated with a lowered risk for PD by about 19% which was seen distinctly among individuals in rural areas, and delayed the age of PD onset. The finding of the presence of pathogenic forms of α-synuclein in human appendix provides insight which may help explore new preventive and treatment strategies against PD.
Science Translational Medicine, 31 Oct 2018 Vol. 10, Issue 465, eaar5280DOI: 10.1126/scitranslmed.aar5280