Sexism among brain tumoursMarch 7, 2019
Yang et al. showed a significant role for sex difference among patients of aggressive brain tumour glioblastoma, marking the need to optimise the therapeutic regimen for each patient. The research identified a remarkable distinction in molecular subtyping among glioblastoma of male and female patients, indicating the need to stratify the tumours for effectiveness of treatment in a sex-specific manner. The researchers performed a quantitative imaging-based measure of response among the patients using MRI scans and survival data from a cancer research database. The cohort of 63 patients involved 40 males and 23 females who received standard chemotherapy. While initial tumour growth velocities were the same, only female patients showed a steady and significant decline in tumour growth. On the application of sophisticated statistical algorithms, the difference in molecular subtypes among males and females were identified, revealing that their survival was driven by very different molecular pathways. The study thus suggests that greater precision in glioblastoma molecular subtyping can be achieved through sex-specific analyses. The researchers suggest that a personalised approach in treatment would greatly improve outcome for the patients in the future.
Source: Science Translational Medicine 02 Jan 2019: Vol. 11, Issue 473, eaao5253 DOI:10.1126/scitranslmed.aao5253 http://stm.sciencemag.org/content/11/473/eaao5253