Oral delivery of insulin via ingestible capsule

April 9, 2019 0 By FM

Abramson et al. developed an ingestible drug delivery vehicle that can be used for oral administration of insulin. The capsule is designed to be able to self-reorient from any starting position so as to attach to the gastric wall. This ingestible self-orienting millimeter-scale applicator (SOMA) autonomously positions itself with the gastrointestinal tissue. Within the capsule, a needle is attached to a compressed spring that is held in place by a disk made of sugar which gets dissolved on reaching the stomach. It then deploys its needles fabricated from active pharmaceutical ingredients directly through the gastric mucosa while avoiding perforation and delivers the active pharmaceutical ingredient. The approach successfully provided active insulin delivery in pigs and rat models. The study demonstrates a less invasive method of drug delivery which can be used to deliver insulin and other protein drugs.

Source: Science 08 Feb 2019: Vol. 363, Issue 6427, pp. 611-615 DOI: 10.1126/science.aau2277 http://science.sciencemag.org/content/363/6427/611