Genome sequence variation may indicate drug targets in individuals

Genome sequence variation may indicate drug targets in individuals

That the genome sequence is unique to each individual human being is not difficult to understand. But if the genome of a number of individuals known to be afflicted with a particular disease is analyzed, it could be possible to identify genes that might serve as targets for therapeutic drugs. This might also explain why individuals suffering the same ailment and living in the same environment respond differently to a particular drug.

Presenting this phenomenon at the 9th NGBT (NextGen, Genomics, Biology, Bioinformatics and Technology) conference held in Mumbai from Sept 30 to Oct 2, 2019, Dr Stephen Michnick explained that therapeutic drugs become a part of the internal ambience of the cell and react with proteins generated within the cell. These existing proteins and the way they behave with each other depends on the gene expression within the cell. Now because of individual variations in the genome, the entire atmosphere known as the Interactome is also different from one person to another.

“We have developed reporter assays that enable us to simultaneously detect the dynamics of thousands of protein-protein interactions,” Professor Michnick explained, drawing upon his research at the Department of Biochemistry, University of Montreal, Canada. The next step would be to examine how chemically induced stresses would change these interactions and whether this information could be used for protein target-specific drug discovery.

The NGBT conference hosted by the SGRF (SciGenome Research Foundation) is an annual platform focused on aiding and encouraging scientific research in India and South Asia and is attended by many industry leaders from across the world.

This is in keeping with the foundation’s commitment to create platforms for scientific exchange and education by organizing high content scientific conferences, seminars and workshops primarily in India and Asia through SGRF Conferences, the educational arm of SGRF.

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