Cytophilic antibodies against key P. falciparumJuly 2, 2018
Asier Garcia-Ikhlaq Hussain Kana et al reports the occurrence of naturally acquired immunity (NAI) against Plasmodium falciparum malaria in a tribal population in a malaria endemic area of India. The clinical trial assessed the quantity and functionality of immunoglobulin G (IgG) antibodies against intact merozoites and recombinant proteins in a 13-month longitudinal cohort study of 121 individuals, 3-60 years of age. Data analysis found opsonic phagocytosis of merozoites activity strongly associated with protection against febrile malaria. Of the different IgG subclasses, only IgG3 antibodies against intact whole merozoites was significantly associated with protection against febrile malaria suggesting that NAI may at least in part be explained by opsonic phagocytosis of merozoites and IgG3 responses against whole merozoites is critical in this population.